Possible Side Effects of ZYNLONTA^®

ZYNLONTA^® (loncastuximab tesirine-lpyl) is a prescription treatment for adults with certain types of large B-cell lymphoma that has come back (relapsed) or that did not respond to previous treatment (refractory), who have already received 2 or
more therapies.

Possible Side Effects of ZYNLONTA^®

Not an actual patient.

Common Side Effects
Tips for Side Effects
Alternative Therapies

Talk to your doctor’s office about serious side effects

Swelling from fluid build up (fluid retention):

Swelling from fluid build up (fluid retention):

This can be a serious side effect.

Tell your doctor’s office if you have new or worsening:

swelling or puffiness
weight gain
chest pain
shortness of breath
trouble breathing

Low blood cell counts (platelets, red blood cells, and white blood cells):

Low blood cell counts (platelets, red blood cells, and white blood cells):

Low blood cell counts are common with ZYNLONTA^®, but that can also be serious or severe. Your doctor will monitor your blood counts during treatment with ZYNLONTA^®.

Tell your doctor’s office right away if you get a fever of 100.4°F (38°C) or above, or if you have any bruising or bleeding.

Infections:

Serious infections, including infections that can cause death, have happened in individuals treated with ZYNLONTA^®.

Tell your doctor’s office right away if you have new or worsening signs or symptoms of infection, including:

fever
chills
flu-like symptoms, like cough, tiredness or weakness, and body aches
headache
breathing problems
cuts or scrapes that are red, warm, swollen or painful

Skin reactions:

Serious skin reactions have been reported in individuals treated with ZYNLONTA^®.

Tell your doctor’s office if you get new or worsening skin reactions, including:

sensitivity to sunlight
a skin rash, peeling, redness or irritation

Your skin may burn more easily or you may get severe sunburns.

Your doctor may change your treatment schedule

If you have severe side effects, your doctor may:

Stop your
treatment
Delay your
treatment
Change your dose
of ZYNLONTA^®

Your doctor will also do blood tests regularly to check for side effects and keep an eye on your response to treatment while you’re on ZYNLONTA^®
You will be monitored for infusion site reactions, infections, and skin reactions. You may also need CT scans to monitor the cancer

Call your doctor for help with serious side effects

The most common side effects of ZYNLONTA^®

Feeling tired or weak
Skin rash
Swelling
Nausea
Muscle or joint pain
Increase in blood sugar (hyperglycemia)
Changes in certain blood or laboratory tests

ZYNLONTA^® may cause fertility problems in males, which may affect your ability to father children. Talk to your doctor if this is a concern for you. These are not all of the possible side effects of ZYNLONTA^®. Call your doctor’s office for medical advice about side effects.

Talk to your doctor’s office about help with side effects

What to avoid during ZYNLONTA^® treatment

If you have certain side effects, your doctor may:

Avoid or limit your exposure to sunlight:

This includes sunlight through glass, such as buildings or vehicle windows and artificial sunlight, such as sunlamps or tanning beds.
If you must go out in the sun, be sure to wear wide brimmed hats and use a high SPF sunscreen.

Exposure to sunlight during treatment with ZYNLONTA^® can cause skin reaction or rash.

Use sun protection measures such as sunscreen and wear loose-fitting clothes that cover your skin while out in sunlight.

Before you receive ZYNLONTA^®,

Before you receive ZYNLONTA^®,

tell your doctor’s office about all of your medical conditions, including if you:

have an active infection or have had one recently
have liver problems
are pregnant or plan to become pregnant because ZYNLONTA^® can harm an unborn baby
are breastfeeding or plan to breastfeed. It is not known if ZYNLONTA^® passes into breast milk. Do not breastfeed during treatment with ZYNLONTA^® and for 3 months after the last dose of ZYNLONTA^®

For females who can become pregnant

If you have certain side effects:

you should use effective birth control (contraception) during treatment with ZYNLONTA^® and for 10 months after the last dose of ZYNLONTA^®
talk to your doctor’s office about effective birth control. Tell your doctor’s office right away if you become pregnant or think that you are pregnant during treatment with ZYNLONTA^®
your doctor’s office may do a pregnancy test before starting treatment with ZYNLONTA^®

For males with female partners who can become pregnant

you should use effective birth control (contraception) during treatment with ZYNLONTA^® and for 7 months after the last dose of ZYNLONTA^®
talk to your doctor’s office about effective birth control. Tell your doctor right away if your partner becomes pregnant during your treatment with ZYNLONTA^®

Reporting side effects

To report side effects to the Food & Drug Administration (FDA): Call (800) FDA-1088 or visit www.fda.gov/medwatch
To report side effects to ADC Therapeutics: Call 1-855-690-0340

Please see the full Prescribing Information for ZYNLONTA^®, including Patient Information, for additional Important Safety Information.

Share a list of medicines you take with your doctor’s office and pharmacist. Include prescription
and over-the-counter medicines, vitamins, and herbal supplements

General tips for common side effects

These are not all of the possible side effects of ZYNLONTA^®. ZYNLONTA^® may cause fertility problems in males. Talk to your doctor if this is a concern for you.

Talk to your doctor about side effects and tips before trying the suggestions below.

Clear all

Feeling tired or weak

Let others help you perform tasks
Balance brief, light exercise with short naps, if needed
Follow good eating and drinking habits. Drink water and limit alcohol and caffeine

Skin rash

Use only mild, gentle soaps
Use a mild, non-perfumed lotion to moisturize
Use sunscreen and skin-covering clothes when going out
Shower in lukewarm (not hot) water

Swelling

Wear loose clothes
Prop up your feet when lying or sitting
Wear compression clothes
Try brief, light exercise
Eat a low-sodium diet. Salt can make swelling worse
Your doctor may prescribe a diuretic, which helps your body rid itself of fluid and salt faster

Muscle or joint pain

Keep track of pain levels and what helps you reduce pain
Take pain medicine as prescribed. Don’t wait until the pain gets to be too much
Consider reaching out to a pain specialist
Ask about alternative therapies

Nausea

Take an anti-nausea medicine
Drink plenty of water and fluids
Avoid foods that make you feel nauseous
Try deep breathing, hypnosis, and other stress-relief routines that help some people with nausea

Increase in blood sugar (hyperglycemia)

You may need to change a few things. Consult your doctor’s office for more information

Changes in certain blood or lab tests

You may need to make a few changes. Your doctor’s office will share ways to help

Complementary therapies

Talk to your doctor about some complementary therapies that may be helpful when used along with your medical treatment. These may be helpful in easing pain caused by lymphoma or its treatment.