Possible Side Effects of ZYNLONTA®

ZYNLONTA® (loncastuximab tesirine-lpyl) is a prescription treatment for adults with certain types of large B-cell lymphoma that has come back (relapsed) or that did not respond to previous treatment (refractory), who have already received 2 or
more therapies.

Not an actual patient.

Talk to your doctor’s office about serious side effects

Swelling from fluid build up (fluid retention):

Fluid retention icon

Swelling from fluid build up (fluid retention):

This can be a serious side effect.

Tell your doctor’s office if you have new or worsening:

  • Swelling or puffiness
  • Weight gain
  • Chest pain
  • Shortness of breath
  • Trouble breathing

Low blood cell counts (platelets, red blood cells, and white blood cells):

Low blood cell count icon

Low blood cell counts (platelets, red blood cells, and white blood cells):

Low blood cell counts are common with ZYNLONTA®, but that can also be serious or severe. Your doctor will monitor your blood counts during treatment with ZYNLONTA®.

Tell your doctor’s office right away if you get a fever of 100.4°F (38°C) or above, or if you have any bruising or bleeding.

Infections:

Infections icon

Infections:

Serious infections, including infections that can cause death, have happened in individuals treated with ZYNLONTA®.

Tell your doctor’s office right away if you have new or worsening signs or symptoms of infection, including:

  • Fever
  • Chills
  • Flu-like symptoms, like cough, tiredness or weakness, and body aches
  • Headache
  • Breathing problems
  • Cuts or scrapes that are red, warm, swollen or painful

Skin reactions:

Skin reactions icon

Skin reactions:

Serious skin reactions have been reported in individuals treated with ZYNLONTA®.

Tell your doctor’s office if you get new or worsening skin reactions, including:

  • Sensitivity to sunlight
  • A skin rash, peeling, redness or irritation

Your skin may burn more easily or you may get severe sunburns.

Your doctor may change your treatment schedule

If you have severe side effects, your doctor may:

  • Stop your treatment icon Stop your
    treatment
  • Delay your treatment iconv Delay your
    treatment
  • Change your dose icon Change your dose
    of ZYNLONTA®
  • Your doctor will also do blood tests regularly to check for side effects and keep an eye on your response to treatment while you’re on ZYNLONTA®
  • You will be monitored for infusion site reactions, infections, and skin reactions. You may also need CT scans to monitor the cancer

Call your doctor for help with serious side effects

The most common side effects of ZYNLONTA®

  • Feeling tired or weak
  • Skin rash
  • Swelling
  • Nausea
  • Muscle or joint pain
  • Increase in blood sugar (hyperglycemia)
  • Changes in certain blood or laboratory tests

ZYNLONTA® may cause fertility problems in males, which may affect your ability to father children. Talk to your doctor if this is a concern for you. These are not all of the possible side effects of ZYNLONTA®. Call your doctor’s office for medical advice about side effects.

Talk to your doctor’s office about help with side effects

What to avoid during ZYNLONTA® treatment

If you have certain side effects, your doctor may:

Avoid or limit your exposure to sunlight:

Sunlight icon

Avoid or limit your exposure to sunlight:

This includes sunlight through glass, such as buildings or vehicle windows and artificial sunlight, such as sunlamps or tanning beds.
If you must go out in the sun, be sure to wear wide brimmed hats and use a high SPF sunscreen.

Exposure to sunlight during treatment with ZYNLONTA® can cause skin reaction or rash.

Use sun protection measures such as sunscreen and wear loose-fitting clothes that cover your skin while out in sunlight.

Before you receive ZYNLONTA®,

Discussion icon

Before you receive ZYNLONTA®,

tell your doctor’s office about all of your medical conditions, including if you:

  • Have an active infection or have had one recently
  • Have liver problems
  • Are pregnant or plan to become pregnant because ZYNLONTA® can harm an unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if ZYNLONTA® passes into breast milk. Do not breastfeed during treatment with ZYNLONTA® and for 3 months after the last dose of ZYNLONTA®

For females who can become pregnant

If you have certain side effects:

  • Your doctor’s office may do a pregnancy test before starting treatment with ZYNLONTA®
  • You should use effective birth control (contraception) during treatment with ZYNLONTA® and for 9 months after the last dose of ZYNLONTA®
  • Talk to your doctor’s office about effective birth control. Tell your doctor’s office right away if your partner becomes pregnant during your treatment with ZYNLONTA®

For males with female partners who can become pregnant

  • You should use effective birth control (contraception) during treatment with ZYNLONTA® and for 6 months after the last dose of ZYNLONTA®
  • Talk to your doctor’s office about effective birth control. Tell your doctor right away if your partner becomes pregnant during your treatment with ZYNLONTA®

Share a list of medicines you take with your doctor’s office and pharmacist. Include prescription
and over-the-counter medicines, vitamins, and herbal supplements

Reporting side effects

Please see the full Prescribing Information for ZYNLONTA®, including Patient Information, for additional Important Safety Information.

Get info on “antibody-drug conjugate” technology

Antibody Drug Conjugate — Also called ADC. A substance made up of a monoclonal antibody (also called mAb) is chemically linked to a drug. The mAb binds to specific proteins found on certain types of cells, including cancer cells. The drug enters these cells and kills them. Some ADCs are used to treat cancer.

 
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Learn how ZYNLONTA® targets cancer

Ask your doctor
about ZYNLONTA®

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Get questions to discuss ZYNLONTA®
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What is ZYNLONTA®?

ZYNLONTA® is a prescription medicine used to treat adults with certain types of large B-cell lymphoma that has come back (relapsed) or that did not respond to previous treatment (refractory), who have already received two or more treatments for their cancer.

It is not known if ZYNLONTA® is safe and effective in children.

The approval of ZYNLONTA® is based on a type of response rate. There is an ongoing study to confirm the clinical benefit of ZYNLONTA®.

IMPORTANT SAFETY INFORMATION

What are the possible side effects of ZYNLONTA®?

ZYNLONTA® may cause serious side effects, including:

  • Fluid retention. Your body may hold too much fluid during treatment with ZYNLONTA®. This can be serious. Tell your healthcare provider if you develop new or worsening swelling or puffiness, weight gain, chest pain, shortness of breath, or trouble breathing
  • Low blood cell counts (platelets, red blood cells, and white blood cells). Low blood cell counts are common with ZYNLONTA® but can also be serious or severe. Your healthcare provider will monitor your blood counts during treatment with ZYNLONTA®. Tell your healthcare provider right away if you get a fever of 100.4°F (38°C) or above, or any bruising or bleeding
  • Read full Important Safety Information
  • Infections. Serious infections, including infections that can cause death, have happened in people treated with ZYNLONTA®. Tell your healthcare provider right away if you have new or worsening signs or symptoms of infection
  • Skin reactions. Serious skin reactions have happened in people treated with ZYNLONTA®. Tell your healthcare provider if you get new or worsening skin reactions, including sensitivity to sunlight, skin rash, peeling, redness or irritation. You may burn more easily or get severe sunburns

The most common side effects of ZYNLONTA® include:

  • feeling tired or weak
  • skin rash
  • swelling
  • nausea
  • muscle or joint pain
  • increase in blood sugar (hyperglycemia)
  • changes in certain blood or laboratory tests

ZYNLONTA® may cause fertility problems in males which may affect your ability to father children. Talk to your healthcare provider if this is a concern for you. These are not all of the possible side effects of ZYNLONTA®.

What should I avoid while receiving ZYNLONTA®?

Avoid or limit your exposure to sunlight, including sunlight through glass, such as buildings or vehicle windows and artificial sunlight such as sunlamps or tanning beds. Exposure to sunlight during treatment with ZYNLONTA® can cause skin reaction or rash. Use sun protection measures such as sunscreen and wear loose-fitting clothes that cover your skin while out in sunlight.

Before you receive ZYNLONTA®, tell your healthcare provider about all of your medical conditions, including if you:

  • have an active infection or have had one recently
  • have liver problems
  • are pregnant or plan to become pregnant. ZYNLONTA® can harm your unborn baby

    Females who can become pregnant:

    • your healthcare provider may do a pregnancy test before starting treatment with ZYNLONTA®
    • you should use effective birth control (contraception) during treatment with ZYNLONTA® and for 9 months after the last dose of ZYNLONTA®. Talk to your healthcare provider about effective birth control. Tell your healthcare provider right away if you become pregnant or think that you are pregnant during treatment with ZYNLONTA®

    Males with female partners who can become pregnant:

    • you should use effective birth control (contraception) during treatment with ZYNLONTA® and for 6 months after the last dose of ZYNLONTA®
  • are breastfeeding or plan to breastfeed. It is not known if ZYNLONTA® passes into breast milk. Do not breastfeed during treatment with ZYNLONTA® and for 3 months after the last dose of ZYNLONTA®

Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get new medicine.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to ADC Therapeutics at 1-855-690-0340.

Please see the full Prescribing Information for ZYNLONTA®, including Patient Information, for additional Important Safety Information.

What is ZYNLONTA®?

ZYNLONTA® is a prescription medicine used to treat adults with certain types of large B-cell lymphoma that has come back (relapsed) or that did not respond to previous treatment (refractory), who have already received two or more treatments for their cancer.

It is not known if ZYNLONTA® is safe and effective in children.

The approval of ZYNLONTA® is based on a type of response rate. There is an ongoing study to confirm the clinical benefit of ZYNLONTA®.

IMPORTANT SAFETY INFORMATION

What are the possible side effects of ZYNLONTA®?

ZYNLONTA® may cause serious side effects, including:

  • Fluid retention. Your body may hold too much fluid during treatment with ZYNLONTA®. This can be serious. Tell your healthcare provider if you develop new or worsening swelling or puffiness, weight gain, chest pain, shortness of breath, or trouble breathing
  • Low blood cell counts (platelets, red blood cells, and white blood cells). Low blood cell counts are common with ZYNLONTA® but can also be serious or severe. Your healthcare provider will monitor your blood counts during treatment with ZYNLONTA®. Tell your healthcare provider right away if you get a fever of 100.4°F (38°C) or above, or any bruising or bleeding
  • Read full Important Safety Information
  • Infections. Serious infections, including infections that can cause death, have happened in people treated with ZYNLONTA®. Tell your healthcare provider right away if you have new or worsening signs or symptoms of infection
  • Skin reactions. Serious skin reactions have happened in people treated with ZYNLONTA®. Tell your healthcare provider if you get new or worsening skin reactions, including sensitivity to sunlight, skin rash, peeling, redness or irritation. You may burn more easily or get severe sunburns

The most common side effects of ZYNLONTA® include:

  • feeling tired or weak
  • skin rash
  • swelling
  • nausea
  • muscle or joint pain
  • increase in blood sugar (hyperglycemia)
  • changes in certain blood or laboratory tests

ZYNLONTA® may cause fertility problems in males which may affect your ability to father children. Talk to your healthcare provider if this is a concern for you. These are not all of the possible side effects of ZYNLONTA®.

What should I avoid while receiving ZYNLONTA®?

Avoid or limit your exposure to sunlight, including sunlight through glass, such as buildings or vehicle windows and artificial sunlight such as sunlamps or tanning beds. Exposure to sunlight during treatment with ZYNLONTA® can cause skin reaction or rash. Use sun protection measures such as sunscreen and wear loose-fitting clothes that cover your skin while out in sunlight.

Before you receive ZYNLONTA®, tell your healthcare provider about all of your medical conditions, including if you:

  • have an active infection or have had one recently
  • have liver problems
  • are pregnant or plan to become pregnant. ZYNLONTA® can harm your unborn baby

    Females who can become pregnant:

    • your healthcare provider may do a pregnancy test before starting treatment with ZYNLONTA®
    • you should use effective birth control (contraception) during treatment with ZYNLONTA® and for 9 months after the last dose of ZYNLONTA®. Talk to your healthcare provider about effective birth control. Tell your healthcare provider right away if you become pregnant or think that you are pregnant during treatment with ZYNLONTA®

    Males with female partners who can become pregnant:

    • you should use effective birth control (contraception) during treatment with ZYNLONTA® and for 6 months after the last dose of ZYNLONTA®
  • are breastfeeding or plan to breastfeed. It is not known if ZYNLONTA® passes into breast milk. Do not breastfeed during treatment with ZYNLONTA® and for 3 months after the last dose of ZYNLONTA®

Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get new medicine.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to ADC Therapeutics at 1-855-690-0340.

Please see the full Prescribing Information for ZYNLONTA®, including Patient Information, for additional Important Safety Information.

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