Resources for Caregivers

Tools and tips to help you and the person you care for navigate DLBCL

Resources for Caregivers

Tools and tips to help you and the person you care for navigate DLBCL

Not an actual patient.

How to know if the person I care for has relapsed or refractory DLBCL

Diffuse Large B-Cell Lymphoma (DLBCL) — A type of B-cell non-Hodgkin lymphoma (cancer of the immune system) that is usually aggressive (fast-growing). It is the most common type of non-Hodgkin lymphoma, and is marked by rapidly growing tumors in the lymph nodes, spleen, liver, bone marrow, or other organs.

 

Conversations with their doctor

Don’t be afraid to ask questions if you don’t understand something. Part of their doctor and their team’s job is to make sure everything is clear.

Write down the questions you may have before the appointment. This can relieve some anxiety and help ensure you don’t forget anything. You can also jot down the doctor’s answers.

Asking questions and having open conversations with their doctor can make a big difference. Here are some general questions you might consider asking about their ZYNLONTA® treatment.

About their treatment

Feel free to download these.

1. Is there anything I can do to help the person I care for through the treatment process?

2. What should I encourage them to do while they are going through treatment?

3. In case of an emergency, where can I find help after hours and on weekends?

4. Which symptoms are more serious than others? When should I call about them?

5. What are the best ways to manage symptoms?

6. Is there anything the person I care for should avoid while they are getting treatment (ie, diet restrictions, physical limitations, etc)?

Planning for the infusion

Ask what to expect or consider throughout treatment.

Download Infusion Chart PDF

Things to consider when planning treatment

Before

How do we get to and from the treatment location?

  • What is the parking like?
  • Are there any transportation services?

What should we know before starting each infusion session?

  • What is the process before infusion?
  • Does the person I care for need to stop eating at a certain time before treatment?
  • What can I do beforehand to make the infusion time better/smoother for the person I care for?

During

What is the total length of each visit?

  • How much time should we block off, and how often?
  • Do we need to stay on-site, or can I leave and come back?
  • Is there a waiting area?

After

How taxing will the treatment be?

  • What will their mood be like upon returning home?
  • How long will they feel this way before the next treatment cycle?

How attentive should I be?

  • How active can they be?
  • Will they need my help with anything?
  • How much independence or space should I give them?

About your role

1. What caregiver resources do you, the clinic, or ADC Therapeutics (the makers of ZYNLONTA®) make available to me?

2. Is there a network or contact for support I can turn to for help?

3. How might helping out affect my day-to-day?

4. Is there anything else I should know that would help me or the person I care for?

Talk to their doctor’s office about serious side effects

Swelling from fluid build up (fluid retention):

Fluid retention icon

Swelling from fluid build up (fluid retention):

This can be a serious side effect.

Tell their doctor’s office if they have new or worsening:

  • swelling or puffiness
  • weight gain
  • chest pain
  • shortness of breath
  • trouble breathing

Low blood cell counts (platelets, red blood cells, and white blood cells):

Low blood cell count icon

Low blood cell counts (platelets, red blood cells, and white blood cells):

Low blood cell counts are common with ZYNLONTA®, but can also be serious or severe. Their doctor will monitor their blood counts during treatment with ZYNLONTA®.

Tell their doctor’s office right away if they get a fever of 100.4°F (38°C) or above, or if they have any bruising or bleeding.

Infections

Infections icon

Infections:

Serious infections, including infections that can cause death, have happened in individuals treated with ZYNLONTA®.

Tell their doctor’s office right away if they have new or worsening signs or symptoms of infection, including:

  • fever
  • chills
  • flu-like symptoms, like cough, tiredness or weakness, and body aches
  • headache
  • breathing problems
  • cuts or scrapes that are red, warm, swollen or painful

Skin reactions:

Skin reactions icon

Skin reactions:

Serious skin reactions have been reported in individuals treated with ZYNLONTA®.

Tell their doctor’s office if they get new or worsening skin reactions, including:

  • sensitivity to sunlight
  • a skin rash, peeling, redness or irritation

Their skin may burn more easily or they may get severe sunburns.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch.
You may also report side effects to ADC Therapeutics at 1-855-690-0340

Financial support

ADVANCING Patient Support (APS) is available to help ZYNLONTA® patients and caregivers. If you’re a caregiver, you can be designated as the contact person on the enrollment form.

Caring for someone with DLBCL is a unique challenge. You shouldn’t have to do it alone. That’s why ADVANCING Patient Support offers resources for caregivers as well.

Once enrolled, reach out to their ADVANCING Patient Support Case Manager (M-F 8 AM-8 PM ET) at 1-855-690-0340 if you have questions about ZYNLONTA® treatment or need additional support.

10 things to know as a caregiver

Feel free to download this.


  • 1

    You are an important member of their care team

    Don’t be afraid to speak up. Ask questions, and take notes during doctor’s visits.

  • 2

    Keep the person you care for involved in their care

    Let them make their own decisions whenever possible. You and their care team can help keep everything on track.

  • 3

    Also take care of yourself

    Take the time to recognize when you are feeling stressed or burned out. Meditate, exercise, get a good rest, see your friends, take some time for yourself—whatever you need to be at your best.

  • 4

    Set boundaries

    Encourage the person you care for to care for themselves as much as they can. This will keep them more engaged in their treatment.

  • 5

    Forgive yourself

    Caregiving is not an exact science. Everyone makes mistakes. Some days you’ll do better than others. Focus on what you did and are doing well.

  • 6

    Don’t try to do everything by yourself

    This is not a solo job. It is a team effort. Reach out for help when you need it. Make a list of the areas where you most need help. Include the names of the people most likely to be able to help.

  • 7

    Have open conversations with the person you care for

    There is a special bond between the caregiver and the one receiving treatment. Make sure you know what they are feeling and thinking, and that they know the same about you.

  • 8

    A positive attitude will take you far

    It’s not always easy to keep your chin up, and that’s okay. But focusing on what’s going well can up your spirits and make things easier.

  • 9

    Education helps

    There are plenty of resources out there for you to learn about lymphoma. Learning more can help you assist the person you care for during doctor visits. It can also help you relate to their experience. What’s more, these resources can help you understand the positives to focus on.

  • 10

    You’re not alone

    Taking advantage of caregiver resources, including online support groups, can ease a lot of the burden. It can also give you an outlet for any stress or frustration you may be feeling.

Additional resources

Learn about
ZYNLONTA® results

Study results icon
Find results for ZYNLONTA®

Get info on antibody-drug conjugate technology

Antibody Drug Conjugate — Also called ADC. A substance made up of a monoclonal antibody (also called mAb) is chemically linked to a drug. The mAb binds to specific proteins found on certain types of cells, including cancer cells. The drug enters these cells and kills them. Some ADCs are used to treat cancer.

 
notebook
Learn how ZYNLONTA® targets cancer
Expand

What is ZYNLONTA®?

ZYNLONTA® is a prescription medicine used to treat adults with certain types of large B-cell lymphoma that has come back (relapsed) or that did not respond to previous treatment (refractory), who have already received two or more treatments for their cancer.

It is not known if ZYNLONTA® is safe and effective in children.

The approval of ZYNLONTA® is based on a type of response rate. There is an ongoing study to confirm the clinical benefit of ZYNLONTA®.

IMPORTANT SAFETY INFORMATION

What are the possible side effects of ZYNLONTA®?

ZYNLONTA® may cause serious side effects, including:

  • Fluid retention. Your body may hold too much fluid during treatment with ZYNLONTA®. This can be serious. Tell your healthcare provider if you develop new or worsening swelling or puffiness, weight gain, chest pain, shortness of breath, or trouble breathing
  • Low blood cell counts (platelets, red blood cells, and white blood cells). Low blood cell counts are common with ZYNLONTA® but can also be serious or severe. Your healthcare provider will monitor your blood counts during treatment with ZYNLONTA®. Tell your healthcare provider right away if you get a fever of 100.4°F (38°C) or above, or any bruising or bleeding
  • Read full Important Safety Information
  • Infections. Serious infections, including infections that can cause death, have happened in people treated with ZYNLONTA®. Tell your healthcare provider right away if you have new or worsening signs or symptoms of infection
  • Skin reactions. Serious skin reactions have happened in people treated with ZYNLONTA®. Tell your healthcare provider if you get new or worsening skin reactions, including sensitivity to sunlight, skin rash, peeling, redness or irritation. You may burn more easily or get severe sunburns

The most common side effects of ZYNLONTA® include:

  • feeling tired or weak
  • skin rash
  • swelling
  • nausea
  • muscle or joint pain
  • increase in blood sugar (hyperglycemia)
  • changes in certain blood or laboratory tests

ZYNLONTA® may cause fertility problems in males which may affect your ability to father children. Talk to your healthcare provider if this is a concern for you. These are not all of the possible side effects of ZYNLONTA®.

What should I avoid while receiving ZYNLONTA®?

Avoid or limit your exposure to sunlight, including sunlight through glass, such as buildings or vehicle windows and artificial sunlight such as sunlamps or tanning beds. Exposure to sunlight during treatment with ZYNLONTA® can cause skin reaction or rash. Use sun protection measures such as sunscreen and wear loose-fitting clothes that cover your skin while out in sunlight.

Before you receive ZYNLONTA®, tell your healthcare provider about all of your medical conditions, including if you:

  • have an active infection or have had one recently
  • have liver problems
  • are pregnant or plan to become pregnant. ZYNLONTA® can harm your unborn baby

    Females who can become pregnant:

    • your healthcare provider may do a pregnancy test before starting treatment with ZYNLONTA®
    • you should use effective birth control (contraception) during treatment with ZYNLONTA® and for 10 months after the last dose of ZYNLONTA®. Talk to your healthcare provider about effective birth control. Tell your healthcare provider right away if you become pregnant or think that you are pregnant during treatment with ZYNLONTA®

    Males with female partners who can become pregnant:

    • you should use effective birth control (contraception) during treatment with ZYNLONTA® and for 7 months after the last dose of ZYNLONTA®
  • are breastfeeding or plan to breastfeed. It is not known if ZYNLONTA® passes into breast milk. Do not breastfeed during treatment with ZYNLONTA® and for 3 months after the last dose of ZYNLONTA®

Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get new medicine.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to ADC Therapeutics at 1-855-690-0340.

Please see the full Prescribing Information for ZYNLONTA®, including Patient Information, for additional Important Safety Information.

What is ZYNLONTA®?

ZYNLONTA® is a prescription medicine used to treat adults with certain types of large B-cell lymphoma that has come back (relapsed) or that did not respond to previous treatment (refractory), who have already received two or more treatments for their cancer.

It is not known if ZYNLONTA® is safe and effective in children.

The approval of ZYNLONTA® is based on a type of response rate. There is an ongoing study to confirm the clinical benefit of ZYNLONTA®.

IMPORTANT SAFETY INFORMATION

What are the possible side effects of ZYNLONTA®?

ZYNLONTA® may cause serious side effects, including:

  • Fluid retention. Your body may hold too much fluid during treatment with ZYNLONTA®. This can be serious. Tell your healthcare provider if you develop new or worsening swelling or puffiness, weight gain, chest pain, shortness of breath, or trouble breathing
  • Low blood cell counts (platelets, red blood cells, and white blood cells). Low blood cell counts are common with ZYNLONTA® but can also be serious or severe. Your healthcare provider will monitor your blood counts during treatment with ZYNLONTA®. Tell your healthcare provider right away if you get a fever of 100.4°F (38°C) or above, or any bruising or bleeding
  • Read full Important Safety Information
  • Infections. Serious infections, including infections that can cause death, have happened in people treated with ZYNLONTA®. Tell your healthcare provider right away if you have new or worsening signs or symptoms of infection
  • Skin reactions. Serious skin reactions have happened in people treated with ZYNLONTA®. Tell your healthcare provider if you get new or worsening skin reactions, including sensitivity to sunlight, skin rash, peeling, redness or irritation. You may burn more easily or get severe sunburns

The most common side effects of ZYNLONTA® include:

  • feeling tired or weak
  • skin rash
  • swelling
  • nausea
  • muscle or joint pain
  • increase in blood sugar (hyperglycemia)
  • changes in certain blood or laboratory tests

ZYNLONTA® may cause fertility problems in males which may affect your ability to father children. Talk to your healthcare provider if this is a concern for you. These are not all of the possible side effects of ZYNLONTA®.

What should I avoid while receiving ZYNLONTA®?

Avoid or limit your exposure to sunlight, including sunlight through glass, such as buildings or vehicle windows and artificial sunlight such as sunlamps or tanning beds. Exposure to sunlight during treatment with ZYNLONTA® can cause skin reaction or rash. Use sun protection measures such as sunscreen and wear loose-fitting clothes that cover your skin while out in sunlight.

Before you receive ZYNLONTA®, tell your healthcare provider about all of your medical conditions, including if you:

  • have an active infection or have had one recently
  • have liver problems
  • are pregnant or plan to become pregnant. ZYNLONTA® can harm your unborn baby

    Females who can become pregnant:

    • your healthcare provider may do a pregnancy test before starting treatment with ZYNLONTA®
    • you should use effective birth control (contraception) during treatment with ZYNLONTA® and for 10 months after the last dose of ZYNLONTA®. Talk to your healthcare provider about effective birth control. Tell your healthcare provider right away if you become pregnant or think that you are pregnant during treatment with ZYNLONTA®

    Males with female partners who can become pregnant:

    • you should use effective birth control (contraception) during treatment with ZYNLONTA® and for 7 months after the last dose of ZYNLONTA®
  • are breastfeeding or plan to breastfeed. It is not known if ZYNLONTA® passes into breast milk. Do not breastfeed during treatment with ZYNLONTA® and for 3 months after the last dose of ZYNLONTA®

Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get new medicine.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to ADC Therapeutics at 1-855-690-0340.

Please see the full Prescribing Information for ZYNLONTA®, including Patient Information, for additional Important Safety Information.