How ZYNLONTA® works
ZYNLONTA® is what’s called an antibody-drug conjugate, or ADC
ZYNLONTA® study results
In a clinical trial, 145 patients with DLBCL that has come back (relapsed) or did not respond to previous treatment (refractory) were treated with ZYNLONTA® to see how well it worked.
Many patients responded to treatment with ZYNLONTA®
aComplete response is the disappearance of all signs of cancer in response to treatment. This does not always mean the cancer has been cured.
bPartial response is a decrease (usually at least 50% in DLBCL) in the size or extent of cancer in the body, in response to treatment.
Patients who received ZYNLONTA® in the study
- Patients had relapsed or refractory large B-cell lymphoma. Most (88%) had a type of disease called DLBCL not otherwise specified (NOS)
- Some had types of disease that are difficult to treat, including DLBCL arising from low-grade lymphoma (20%), or high-grade B-cell lymphoma (8%)
- Age range was from 23 to 94 (median: 66). More than half (59%) were male. And most were Caucasian (90%)
- Patients had at least 2 and as many as 7 therapies before ZYNLONTA®
- Some had a previous stem cell transplant (17%), while some had received CAR-T-cell therapy (9%)
- More than half of patients (63%) did not respond to their previous treatment
CAR-T = chimeric antigen receptor T cell; DLBCL = diffuse large B-cell lymphoma.
How ZYNLONTA® is given
How will I receive ZYNLONTA®?
ZYNLONTA® is given by intravenous (IV) infusion by a trained healthcare provider at a clinic or infusion center through a needle placed in a vein. You will receive an IV infusion once every 3 weeks. Each infusion lasts 30 minutes.
Your healthcare provider will decide how many treatments you need.
Before every ZYNLONTA® treatment, you may be given a prescription steroid to take twice a day for 3 days, starting the day before your infusion. Your healthcare provider will determine if this is appropriate for you and may choose to give you the steroid as an oral medication or IV infusion.
What may affect your treatment
Your healthcare provider may stop your treatment, delay your treatment, or change your dose of ZYNLONTA® if you have certain side effects. Your healthcare provider will do blood tests regularly to check for side effects of ZYNLONTA®.